Randomized prospective trial comparing the native prothrombin antigen with the prothrombin time for monitoring oral anticoagulant therapy
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منابع مشابه
Randomized prospective trial comparing the native prothrombin antigen with the prothrombin time for monitoring oral anticoagulant therapy.
The dosage of the anticoagulant warfarin sodium is based upon the prolongation of the prothrombin time into an optimal therapeutic range. We have developed a new assay for the native prothrombin antigen that measures the fully gamma-carboxylated prothrombin using a radioimmunoassay. Based on preliminary data that indicated that the native prothrombin antigen predicted both bleeding and thrombot...
متن کاملComparison of the native prothrombin antigen and the prothrombin time for monitoring oral anticoagulant therapy.
We have measured the fully carboxylated (native) prothrombin antigen and the undercarboxylated (abnormal) prothrombin antigen in patients treated with sodium warfarin using specific immunoassays to evaluate a new approach for monitoring oral anticoagulant therapy. Plasma and serum samples (391) were assayed for the prothrombin time, native prothrombin antigen, and abnormal prothrombin antigen. ...
متن کاملHas the time arrived to replace the quick prothrombin time test for monitoring oral anticoagulant therapy?
The Quick (1 ) and Owren (2 ) prothrombin time (PT) tests remain the basis for monitoring anticoagulant therapy worldwide. The use of these tests is remarkable because the Quick PT preceded the discovery of the anticoagulant effect of dicoumarol in spoiled sweet clover and both tests were in use long before there was any understanding of the mechanism of the action of oral anticoagulants or whi...
متن کاملCost-minimisation analysis of oral anticoagulant therapy monitoring methods: the case for prothrombin time self-monitoring.
INTRODUCTION Anticoagulant therapy is usually chronic and is indicated for the treatment of several medical conditions. The most common of these include patients with mechanical heart valves and those suffering from atrial fibrillation. METHODS This study compares two methods of oral anticoagulant therapy (OAT) monitoring: traditional prothrombin time measurement and self-measuring or self-re...
متن کاملA critical evaluation of the prothrombin time for monitoring oral anticoagulant therapy.
The Quick prothrombin time is the most common clotting test performed, principally for monitoring oral anticoagulant therapy. The International Normalized Ratio (INR) for comparing patient results from prothrombin time measurements and the International Standardized Index (ISI) for achieving greater consistency of results using different thromboplastins have made it possible to compare the resu...
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ژورنال
عنوان ژورنال: Blood
سال: 1990
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v75.2.344.344